Pravasi Bharatiya Divas

The Pravasi Bharatiya Divas (PBD) celebrated once in two years on 9th January is a significant event that honors the contributions of the Indian diaspora to their homeland. The Pravasi Bharatiya Divas (PBD) Convention was first established in 2003 under the government of then Prime Minister Late Shri Atal Bihari Vajpayee, as a platform to recognize and engage with the overseas Indian community.

The Pravasi Bharatiya Divas is the flagship event of the Ministry of External Affairs. It is held in different cities, to showcase the diversity and progress of different regions of India. Since 2015, it has evolved into a biennale event, with theme-based conferences held in the intervening years. This format allows for more focused discussions on specific areas of interest and provides opportunities for networking among the global Indian diaspora.

Nano-formulation of darkness hormone could be therapeutic solution for Parkinson's disease

Scientists have proved that nano-formulation of Melatonin, the hormone produced by the brain in response to darkness, showed improved antioxidative and neuroprotective properties and could be a potential therapeutic solution for Parkinson's disease (PD). Parkinson's disease (PD) is one of the most common neurological disorders caused by the death of dopamine-secreting neurons in the brain due to aggregation of synuclein protein inside it. Available medications can only minimize the symptoms but cannot cure the disease and this underlines the need to develop better therapeutic solutions for the disease.

Studies over the last decade have shown the implications of PD-related genes in governing a quality control mechanism called "Mitophagy", which identifies and removes dysfunctional mitochondria and reduces oxidative stress. Among many antioxidants, melatonin, a neurohormone secreted from the pineal gland, an endocrine gland present in the brain, that regulates the sleep-wake cycle and is used to treat insomnia could be a potential inducer of mitophagy to mitigate PD.

The molecular pathways melatonin follows as a PD antagonist, remain poorly elucidated, despite being a safe and a potential neurotherapeutic drug with a few limitations like less bioavailability, premature oxidation, brain delivery, etc. A group of researchers from the Institute of Nano Science and Technology (INST) Mohali, an autonomous institute of the Department of Science and Technology (DST) used human serum albumin nano-formulation to deliver the drug to the brain and studied the molecular mechanism behind melatonin-mediated oxidative stress regulation. Using a biocompatible protein (HSA) nanocarrier for the delivery of melatonin to the brain, Dr. Surajit Karmakar and his team have proved that the nano-melatonin resulted in a sustained release of melatonin and improved bioavailability.

They found that the nano-melatonin demonstrated enhanced antioxidative and neuroprotective properties. It not only improved mitophagy to remove unhealthy mitochondria but also improved mitochondrial biogenesis to counteract a pesticide (rotenone) induced toxicity in an in vitro PD model. The improvement is attributed to the sustained release of melatonin and targeted delivery to the brain resulting in increased therapeutic efficacy compared to bare melatonin. The increased antioxidative effect is a result of mitophagy induction through the upregulation of a crucial epigenetic regulator called BMI1 that controls gene expression. The reduction in oxidative stress contributes to alleviating the symptoms of Parkinson's disease.

Their findings published in the journal ACS Applied Materials & Interfaces highlighted the significantly better in vitro and in vivo neuroprotective effect of nano-melatonin as well as the molecular/cellular dynamics it influences to regulate mitophagy. The experiments showed that the nano-formulation of melatonin also protected TH-positive neurons in the brains of rats against rotenone-mediated toxicity. Additionally, the study revealed for the first time that BMI1, a member of the Polycomb Repressive Complex 1, the most essential family of proteins responsible for epigenetic regulation, was overexpressed following nano-formulation treatment. This overexpression-induced mitophagy could help in protecting neurons from degeneration.

The study unfurls the molecular mechanism behind melatonin-mediated mitophagy regulation. Enhanced mitophagy was crucial to reduce oxidative stress in the Parkinson's disease model. Melatonin-mediated BMI1 regulation and the latter's role in inducing mitophagy to curb oxidative stress could set a path for establishing melatonin as a therapeutic candidate for Parkinson’s Disease. It can also be used to treat other diseases where dysregulated mitophagy is critical for pathological outcomes. With continued exploration, this could be established as a safer drug to improve the lives of patients.

National Sports Awards 2024

National Sports Awards are given every year to recognize and reward excellence in sports. Major Dhyan Chand Khel Ratna Award is given for the spectacular and most outstanding performance in the field of sports by a sportsperson over the period of the previous four years. Arjuna Award for outstanding performance in Sports and Games is given for good performance over a period of the previous four years and for showing qualities of leadership, sportsmanship and a sense of discipline. Arjuna Award (Lifetime) is given to honour and motivate those sportspersons who have contributed to sports by their performance and continue to contribute to promotion of sports even after their retirement from active sporting career. Dronacharya Award for Outstanding Coaches in Sports and Games is given to coaches for doing outstanding and meritorious work on a consistent basis and for enabling sportspersons to excel in International events. The overall top performing university in Khelo India University Games is given the Maulana Abul Kalam Azad (MAKA) Trophy.

Click Here to Read the Complete Winner List

What is HMPV Virus Currently Spreading in China?

Introduction

Human Metapneumovirus (HMPV) has recently been making headlines in China due to a sudden rise in infections. While not as well-known as other respiratory viruses like the flu or COVID-19, HMPV can have serious implications, especially for the elderly, children, and those with weakened immune systems. As concerns grow about its spread, understanding this virus and how to prevent it becomes essential.

In this article, we’ll dive into everything you need to know about HMPV, its symptoms, the current situation in China, and, most importantly, how you can protect yourself and your loved ones.

Understanding the HMPV Virus

What is HMPV (Human Metapneumovirus)?

HMPV is a respiratory virus first identified in 2001. It belongs to the Paramyxoviridae family, which also includes other well-known viruses like measles and mumps. HMPV primarily affects the respiratory tract, causing symptoms that range from mild to severe.

Despite being relatively new to the spotlight, studies suggest that HMPV has been circulating in humans for decades. It is a leading cause of respiratory illness, especially during late winter and early spring.

How is HMPV Transmitted?

HMPV spreads much like the common cold or flu. The primary modes of transmission include:

• Direct contact: Shaking hands or touching contaminated surfaces.
• Respiratory droplets: Coughing, sneezing, or talking close to others.
• Touching the face: Transferring the virus from the hands to the eyes, nose, or mouth.

Risk factors for transmission are similar to other respiratory viruses, including crowded environments, poor ventilation, and weakened immune systems.

Symptoms of HMPV Infection

HMPV symptoms often mimic those of the flu or other respiratory infections. Common signs include:

• Coughing
• Nasal congestion
• Fever
• Shortness of breath
• Fatigue

In severe cases, HMPV can lead to complications like bronchitis or pneumonia, particularly in vulnerable groups such as infants, older adults, and people with chronic health conditions.

Preventive Measures for HMPV

Hygiene Practices

Basic hygiene is your first line of defense:

• Wash your hands frequently with soap and water for at least 20 seconds.
• Use hand sanitizers with at least 60% alcohol when soap isn’t available.
• Avoid touching your face, especially your eyes, nose, and mouth.

Social Distancing and Mask Usage

Face masks and social distancing, proven effective during the COVID-19 pandemic, remain valuable tools in controlling HMPV’s spread. Masks can block respiratory droplets while maintaining physical distance reduces the risk of direct transmission.

Strengthening Immunity

A robust immune system can help fend off HMPV. Focus on:

• A balanced diet: Include plenty of fruits, vegetables, and whole grains.
• Regular exercise: Aim for at least 30 minutes of moderate activity most days.
• Adequate sleep: Poor sleep can weaken immune defenses.
• Supplements: Vitamins C and D, along with zinc, may provide added protection.

National Quantum Mission (NQM)

Introduction: It will be implemented by the Department of Science and Technology (DST) under the Ministry of Science and Technology. The objective of the mission planned for the year 2023-2031 is to sow, nurture, and scale up scientific and industrial R&D. It also aims to build a vibrant and innovative ecosystem in Quantum Technology (QT). With this mission, India will become the seventh country (along with the US, Austria, Finland, France, Canada, and China) to implement a dedicated quantum mission.

Mission Highlights: It aims to develop intermediate-scale quantum computers of 50-100 physical qubits in the next 5 years and 50-1000 physical qubits in 8 years. Just as bits (Is and 0s) are the basic units by which computers process information, 'qubits' or 'quantum bits' are the units used by quantum computers. The mission will help develop precision timing (atomic clocks), and high sensitivity magnetometers for communication and navigation. It will also support the design and synthesis of quantum materials such as superconductors, novel semiconductor structures, and topological materials for building quantum devices.

The mission will also help in the development of:

• Satellite-based secure quantum communication between ground stations within India within a range of 2000 km.
• Long-distance secure quantum communication with other countries
• Inter-city quantum key distributions over 2000 km.
• Multi-node quantum networks with quantum memory.

Significance: It will accelerate quantum technology-driven economic growth and make India one of the leading nations in developing Quantum Technologies and Applications (QTA) in diverse sectors such as healthcare and diagnostics, defence, energy, and data security. It will work towards indigenously building quantum-based com¬puters that are far more efficient and capable of solving the most complex problems in a highly secure.

COP29: Agenda, Goals, and Potential Outcomes

Introduction to COP29

The 29th session of the Conference of the Parties (COP29) marks a pivotal event in global efforts to tackle climate change. With the recent surge in extreme weather events, rising global temperatures, and persistent calls for climate action, COP29 brings together global leaders, scientists, advocates, and policymakers to address urgent climate concerns. COP29 offers a significant opportunity to evaluate progress, renew commitments, and create actionable plans that contribute to the collective goal of curbing climate change.

What is COP29?

COP29, part of the annual United Nations Framework Convention on Climate Change (UNFCCC) conferences, gathers representatives from nearly 200 countries to discuss climate policy and agreements. Each COP is a platform for assessing climate challenges, negotiating terms for emissions reductions, and securing international cooperation. This year's conference will likely attract thousands of delegates, with an emphasis on bridging the gap between developing and developed nations.

Historical Context of COP Conferences

Understanding COP29’s objectives requires looking back at major achievements from previous COP sessions:

• Kyoto Protocol (COP3): Established binding commitments for developed nations to reduce greenhouse gas emissions.
• Paris Agreement (COP21): This landmark accord saw almost all nations agree to limit global temperature rise to well below 2°C, with efforts to restrict it to 1.5°C.
• Glasgow Climate Pact (COP26): Reaffirmed the urgency of reducing emissions and pledged to phase down coal and fossil fuel subsidies.

Each COP builds upon the past, with COP29 expected to address unfinished agendas and advance new climate actions.

COP29 Agenda: Key Issues and Priorities

COP29’s agenda will revolve around:

• Adaptation and Mitigation: A core focus on strategies that protect communities from climate impacts while reducing emissions.
• Global Temperature Goals: Reaffirming the commitment to limit temperature rise to 1.5°C.
• Long-term Emission Reduction Targets: Setting and refining targets for countries to achieve net-zero emissions by mid-century.

These topics aim to fortify global resilience against climate impacts, protect ecosystems, and build momentum toward a sustainable future.

Climate Finance: Funding for Developing Nations

Climate finance remains a central issue at COP29, especially regarding support for developing countries disproportionately impacted by climate change. Developed nations previously committed to providing $100 billion annually, but this goal must still be met. At COP29, countries are expected to discuss new mechanisms, such as:

• Innovative Funding Tools: Mechanisms like carbon trading, debt relief for green investments, and global tax schemes.
• Direct Investment in Green Infrastructure: Boosting renewable energy projects, sustainable agriculture, and climate-resilient infrastructure in vulnerable regions.

Loss and Damage: A Focus on Climate Justice

Loss and damage refer to the adverse impacts that vulnerable nations face due to climate change. This year, COP29 will likely revisit the loss and damage fund, initiated at COP27, which aims to provide financial support for countries facing irreversible climate impacts. Key goals include:

• Operationalizing the Fund: Finalizing the governance structure and resource allocation for loss and damage funding.
• Broadening Financial Support: Gaining contributions from both public and private sectors to meet the needs of affected communities.

Reducing Fossil Fuel Dependence

With fossil fuels accounting for a major share of global emissions, COP29 will likely prioritize actions to decrease reliance on coal, oil, and natural gas. Goals in this area include:

• Transition to Renewable Energy: Increasing commitments for clean energy sources like wind, solar, and hydro.
• Phasing Out Coal: Continuing efforts to reduce coal consumption, especially in high-emission sectors.
• Reducing Fossil Fuel Subsidies: Redirecting financial support from fossil fuels to renewable energy.

Adaptation Strategies for Resilient Societies

While mitigation seeks to reduce emissions, adaptation focuses on preparing societies to live with the impacts of climate change. COP29 is set to enhance adaptation strategies that strengthen resilience, particularly for vulnerable regions:

• Climate-Resilient Agriculture: Supporting farming practices that withstand extreme weather.
• Coastal Protection Initiatives: Building defenses against rising sea levels for island nations and coastal communities.
• Community-Based Adaptation: Engaging local communities in planning and implementing adaptation measures.

Sustainable Development Goals and Climate

The UN Sustainable Development Goals (SDGs) aim for a holistic approach to sustainability. COP29’s discussions will emphasize:

• Integration with SDGs: Addressing climate change in ways that support broader development goals, such as reducing poverty and improving health.
• Cross-Sector Collaboration: Recognizing the interconnectedness of climate, economy, and society.

By aligning with the SDGs, COP29 reinforces the idea that climate solutions should advance both environmental and human welfare.

Technology and Innovation in Climate Solutions

Technological innovation is key to achieving ambitious climate goals, and COP29 will highlight several tech-driven initiatives:

• Carbon Capture and Storage (CCS): Technologies designed to capture and store carbon emissions from industrial sources.
• Renewable Energy Advancements: Innovations in energy storage, grid management, and renewable energy production.
• Smart Agriculture: Using technology to reduce agricultural emissions, improve yields, and enhance food security.

Youth and Indigenous Leadership in Climate Action

COP29 will focus on increasing youth and Indigenous voices in climate discussions, recognizing the essential role these groups play in shaping sustainable futures:

• Youth Empowerment: Amplifying youth-led initiatives and campaigns.
• Indigenous Knowledge: Leveraging indigenous practices for conservation, biodiversity, and land management.

Expected Commitments from Major Nations

At COP29, commitments from major economies like the United States, China, the European Union, and India will be crucial. Expected areas of focus include:

• Strengthened Nationally Determined Contributions (NDCs): Enhancing emission reduction targets and deadlines.
• Support for Developing Countries: Allocating funds, technology, and capacity-building resources.

Monitoring and Accountability: Ensuring Progress

To avoid unfulfilled promises, COP29 will emphasize robust monitoring mechanisms. This includes:

• Transparent Reporting: Requiring countries to report progress openly.
• Accountability Measures: Holding countries accountable for missed targets.

Challenges Facing COP29

Despite global urgency, COP29 faces numerous challenges, such as:

• Political Conflicts: Disagreements between developed and developing nations over responsibilities and funding.
• Economic Pressures: Balancing climate goals with economic growth, especially for fossil-fuel-dependent countries.

Potential Outcomes of COP29

COP29’s outcomes could range from ambitious commitments to incremental progress:

• Best-Case Scenario: Global consensus on strong emission reductions, climate finance, and adaptation measures.
• Moderate Outcome: Limited but notable progress with enhanced pledges from a subset of nations.
• Worst-case scenario: Stalemates that leave critical issues unresolved.

Conclusion: The Road Ahead Post-COP29

COP29 offers an essential platform to renew commitments, establish new financial mechanisms, and drive significant climate action. The urgency of climate change requires not only strong policies but also an unwavering commitment to a sustainable future.

FAQs

Q. What is COP?
ANS: COP stands for Conference of the Parties, an annual climate summit organized by the UN to address climate policy.

Q. How do COP decisions affect daily life?
ANS: COP agreements influence global policies on energy, agriculture, and industry, which impact daily life through regulations, funding, and environmental protection efforts.

Q. What are the key goals for COP29?
ANS: COP29 focuses on emission reductions, climate finance, and strengthening resilience against climate impacts.

Q. What role does technology play at COP29?
ANS: Technology supports emission reduction, energy efficiency, and adaptation strategies essential for meeting climate goals.

Q. How will COP29 impact future climate policies?
ANS: COP29’s outcomes will shape future climate policies, influencing global cooperation, funding, and targets for years to come.

Gujarat becomes India’s first state to implement a dedicated semiconductor policy

Gujarat's Groundbreaking Semiconductor Policy 2022-2027: Paving the Path for India’s Semiconductor Self-Reliance

The Gujarat government has launched India's first Gujarat Semiconductor Policy 2022-2027, marking a major step toward semiconductor self-reliance. Spearheaded by Chief Minister Bhupendra Patel, this ambitious initiative aims to establish Gujarat as a prominent player in India’s semiconductor landscape, driven by the newly established Gujarat State Electronics Mission.

Major Projects Transforming Gujarat’s Semiconductor Industry

Under this visionary policy, significant investments are reshaping Gujarat's semiconductor capabilities. Recently, Chief Minister Patel inaugurated the construction of Micron’s advanced semiconductor ATMP (Assembly, Test, Mark, and Pack) plant in Sanand, an enterprise worth over ₹22,500 crore. This plant is a pivotal development under the Gujarat Semiconductor Policy, symbolizing the state's drive toward advanced semiconductor assembly capabilities.

In addition, Tata Electronics Private Limited (TEPL) and Taiwan’s Powerchip Semiconductor Manufacturing Corporation (PSMC) have committed to establishing India’s first AI-enabled semiconductor fabrication facility in Dholera’s planned "Semicon City." This monumental project, valued at more than ₹91,000 crore, signifies Gujarat's strategic alignment with AI-enhanced semiconductor production and is expected to drive substantial economic growth.

Expanded Infrastructure with OSAT and High-Capacity Chip Production Facilities

The policy also supports new ventures by CG Power and Renesas, who are jointly setting up a state-of-the-art Outsourced Semiconductor Assembly and Test (OSAT) facility in Sanand, totaling an investment of ₹7,500 crore. This facility will bolster Gujarat’s semiconductor testing and packaging infrastructure, essential for producing high-quality, globally competitive semiconductor products.

Additionally, Kaynes Semicon has received government approval to build a semiconductor production plant in Sanand with an anticipated daily output of 6 million chips. Backed by an investment of ₹3,300 crore, this facility is expected to further advance Gujarat's semiconductor manufacturing capacity, generating a substantial number of highly skilled jobs.

Incentives and Financial Support for Semiconductor Investments in Gujarat

Recognizing the intensive capital requirements of the semiconductor industry, Gujarat’s Semiconductor Policy provides a variety of financial incentives to encourage investment. These include:

• 40% Capital Expenditure Subsidy: A unique incentive offered by Gujarat to assist with high upfront costs.
• 100% Stamp Duty and Registration Fee Refund: A one-time refund of all stamp duty and registration fees for semiconductor businesses.
• Energy and Water Subsidies: A subsidy of ₹2 per unit on electricity and water provision at a competitive rate of ₹12 per cubic meter.
• Land Acquisition Subsidy: Up to 75% land acquisition subsidy for semiconductor units established in Dholera, promoting the development of the Greenfield Smart City as India’s first "Semicon City."

These financial incentives, designed to reduce costs and encourage large-scale semiconductor production, are bolstering Gujarat’s position as a top destination for high-tech investments.

Dholera’s Semicon City: A Strategic Hub for India’s Semiconductor Ambitions

The policy’s focus on Dholera as India’s first Greenfield Smart City adds a strategic layer to Gujarat’s semiconductor ambitions. Branded as Semicon City, this area is specifically designed to attract semiconductor manufacturing and fabrication investments. As part of this vision, Dholera aims to foster an ecosystem that supports the semiconductor supply chain, research, and technological advancement, positioning it as a pivotal center for India’s semiconductor industry.

Significant Investment Commitments Drive Employment and Economic Growth

Gujarat’s semiconductor initiatives have already attracted commitments from four major industry players, with a cumulative investment of ₹1.24 lakh crore. This wave of investment is expected to generate approximately 53,000 jobs, offering a substantial boost to local employment and skill development in high-tech fields.

Alignment with India’s National Semiconductor Mission

Gujarat’s state-level efforts align seamlessly with the India Semiconductor Mission, introduced by the central government in 2021 with a budget of ₹76,000 crore. This mission aims to strengthen domestic semiconductor production, meeting rising demand across sectors such as telecommunications, automotive, consumer electronics, and data centers. As of 2020, India’s semiconductor market was valued at $15 billion and is anticipated to exceed $63 billion by 2026, demonstrating the potential for exponential growth in the coming years.

Conclusion: A New Era of Semiconductor Development in Gujarat

With the Gujarat Semiconductor Policy 2022-2027, the state is setting a new standard for semiconductor development in India. By fostering significant investment, offering substantial financial support, and creating specialized infrastructure like Semicon City, Gujarat is positioning itself as a powerhouse for semiconductor innovation. The policy not only supports India’s goal of self-reliance but also aligns with global industry trends, ensuring that Gujarat plays a leading role in the country’s technology-driven future.