The Nobel Prize in Physiology or Medicine 2024 given to Victor Ambros (Affiliation at the time of the award: UMass Chan Medical School, Worcester, MA, USA) and Gary Ruvkun (Affiliation at the time of the award: Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA) for the discovery of microRNA and its role in post-transcriptional gene regulation.
The information stored within our chromosomes can be likened to an instruction manual for all cells in our body. Every cell contains the same chromosomes, so every cell contains exactly the same set of genes and exactly the same set of instructions. Yet, different cell types, such as muscle and nerve cells, have very distinct characteristics. How do these differences arise? The answer lies in gene regulation, which allows each cell to select only the relevant instructions. This ensures that only the correct set of genes is active in each cell type.
